Grants

CCHIDS unites world-class health informatics and data science researchers and combines contributions to promote health and health equity at community, national, and international levels.

Current

Reducing Health Disparities Through Informatics (RHeaDI)

Principal Investigators: Rebecca Schnall, Suzanne Bakken

Funding: National Institute of Nursing Research

The Reducing Health Disparities Through Informatics (RHeaDI) training program supports interdisciplinary research training for pre- and postdoctoral nurse scientists focused on the use of informatics and data science approaches to advance health equity, holistic and precision health, and facilitate evidence-based practice in underserved populations.

A National Report of Nursing Home Quality Measures and Information Technology

Principal Investigator: Gregory Alexander

Funding: Agency for Healthcare Research and Quality

This study examines the relationships between nursing home (NH) information technology (IT) Maturity and stages of maturity, and nationally-reported, publicly-available NH Quality Measures available through Nursing Home Compare over multiple consecutive years.

Impact of Nursing Home Leadership Care Environments and Health Information Technology on Outcomes of Residents with Dementia

Principal Investigators: Gregory Alexander, Lusine Poghosyan

Funding: National Institute of Aging

This study examines the impact of nursing home health information technology (HIT) maturity and nurse practitioner care environments on outcomes of residents with Alzheimer’s Disease and Related Dementias including hospitalizations and emergency department visits.

Reaching Communities through the Design of Information Visualizations (ReDIVis) Toolbox for Return of COVID-19 Results

Principal Investigators: Suzanne Bakken, Adriana Arcia

Funding: National Institute of Nursing Research

The overall goal of Reaching Communities through the Design of Information Visualizations (ReDIVis) Toolbox for Return of COVID-19 Results (RCR) is to decrease health disparities related to COVID-19 by enabling widespread use of culturally congruent and health literate infographics to return the results of SARS-CoV-2 diagnostic and antibody testing in a manner that supports comprehension of the results, informs decision making, and motivates appropriate behaviors.

Reaching Communities through the Design of Information Visualizations (ReDIVis) Toolbox to Address COVID-19 Vaccine Hesitancy and Uptake

Principal Investigators: Suzanne Bakken, Adriana Arcia

Funding: National Institute of Nursing Research

The overall goal of Reaching Communities through the Design of Information Visualizations Toolbox (ReDIVis Toolbox: Vaccination) is to decrease health disparities related to COVID-19 vaccination in underserved and vulnerable populations by enabling widespread use of culturally congruent and health literate infographics to decrease vaccine hesitancy and improve vaccine uptake in a manner that is comprehensible, informs decision making, and motivates appropriate behaviors. 

The Interdisciplinary Guided Network for Investigation, Translation and Equity (IGNITE) for All of Us Research Program

Principal Investigators: Elizabeth Cohn, Site PI: Suzanne Bakken

Funding: NIH Office of the Director

The Interdisciplinary Guided Network for Investigation, Translation, and Equity (IGNITE) was developed to work with NIH to meet the near-term and long-term programmatic goals by enhancing the use of the All of Us Research Program data by diverse groups including community-based organizations and clinicians.

Telemedicine for Patients with Limited English Proficiency: A Mixed Methods Approach to Identifying and Addressing Disparities

Principal Investigator: Natalie Benda

Funding: Agency for Healthcare Research and Quality

This study uses a mixed methods sequential explanatory design approach to identify and address barriers and facilitators related to providing telemedicine care to patients with limited English proficiency, with a focus on the intersection of other social determinants of health. 

Maternal Outcome Monitoring and Support (MOMS) - A mHealth symptom self-monitoring and decision support system to reduce racial and ethnic disparities in postpartum outcomes

Principal Investigator: Natalie Benda

Funding: National Institute on Minority Health and Health Disparities

This study is developing a mHealth-based, patient-reported outcome and decision-support system to help African-American and Spanish-speaking Latina women determine when to seek care for warning signs of severe maternal morbidity.

Characterizing and Addressing Financial Toxicity in Adolescents and Young Adults with Cancer

Principal Investigator: Melissa Beauchemin

Funding: National Center for Advancing Translational Sciences

This study is characterizing and addressing financial toxicity in adolescents and young adults with cancer

Randomized comparison of the clinical Outcome of single versus Multiple Arterial grafts: Quality of Life (ROMA:QOL)

Principal Investigators: Ruth Masterson Creber, Mario Gaudino

Funding: National Heart, Lung, and Blood Institute

This study is focused on defining the impact of coronary artery bypass graft (CABG) surgery on health-related quality of life and symptom burden among 2,111 men and women with multi- vessel coronary artery disease in the context of the large multinational ROMA trial that is testing the hypothesis that clinical outcomes with multiple arterial grafts are superior to single arterial graft over 5 years. 

Randomized comparison of the clinical Outcome of single versus Multiple Arterial grafts: Cognition (ROMA:Cog)

Principal Investigators: Ruth Masterson Creber, Mario Gaudino, Richard Swartz

Funding: National Institute of Neurological Disorders and Stroke

The primary objective of this study is to reduce cognitive impairment after coronary artery bypass graft (CABG) surgery. The central hypothesis is that CABG using multiple arterial grafts will be associated with less cognitive impairment than CABG with single arterial grafts, due to less intraoperative aortic manipulation, better patency of arterial compared to saphenous grafts, and lower risk of revascularization. 

Improve the Meaning of Patient Reported Outcomes to Evaluate Effectiveness for Cardiac Care" (IMPROVE-Cardiac Care)

Principal Investigator: Ruth Masterson Creber

Funding: National Heart, Lung, and Blood Institute

The overall goal of the Improve the Meaning of Patient-Reported Outcomes to eValuate Effectiveness for Cardiac Care” (IMPROVE: Cardiac Care) study is to establish population and individual minimally clinically important differences (MCIDS) in patient-reported outcomes, which are the smallest improvement that is meaningful to patients with cardiac conditions.

mHealth and Mobile Ultrasound for Mothers in Myanmar (mMUMM)

Principal Investigator: Ruth Masterson Creber

Funding: National Institute on Minority Health and Health Disparities    

The dual objectives of the “mHealth and Mobile Ultrasound for Mothers in Myanmar” (mMUMM) stepped-wedge cluster randomized trial are to evaluate: (1) the utility of using a mobile health (mHealth) application to collect population surveillance data, and (2) the effectiveness of using a portable ultrasound device to improve the rates of attended births and successful transfers for high-risk pregnancies to a hospital.

Using Mobile Integrated Health and Telehealth to Support Transitions of Care among Heart Failure Patients

Principal Investigator: Ruth Masterson Creber

Funding: Patient Center Outcomes Research Institute

In this study, the research team is comparing two ways to improve the follow-up care that patients with heart failure receive after returning home from the hospital on return visits to the hospital and prescriptions for heart failure medicine. In the first type, patients receive a phone call from a care transitions coordinator two to three days after discharge. The coordinator checks on patients, answers their questions, and connects them to clinical and social services. In the second type, called mobile integrated health, patients receive a follow-up phone call from a nurse. Patients also have access to community paramedics, who can provide emergency medical care in patients’ homes or take them to the hospital.

Communicating narrative Concerns entered by RNs (CONCERN)

Principal Investigators: Sarah Rossetti, Kenrick Cato

Funding: National Institute of Nursing Research

The aim of this project is to design and evaluate a SMARTapp on FHIR used across two large academic medical centers that exposes to physicians and nurses our new predictive data source from nursing documentation to increase care team situational awareness of at-risk patients to decrease preventable adverse outcomes. 

CONCERN Implementation Toolkit: Advancing technology-enabled nursing expertise and equitable predictions

Principal Investigator: Sarah Rossetti

Funding: American Nurses Foundation

This project is bundling the CONCERN knowledge assets into an implementation toolkit to foster increased reach and scale.

Essential Nurse Documentation: Studying EHR Burden during COVID-19 (ENDBurden)

Principal Investigators: Sarah Rossetti, Po-Yin Yen

Funding: Agency for Healthcare Research and Quality

The specific aims of this project are to examine changes in the temporal trends of data entry and data viewing patterns of nursing, investigate how nurses define and decide what is essential to document for patient care and the impact of all-inclusive documentation on EHR burden, and examine changes in data entry and data viewing patterns of nursing documentation and the impact of these changes on patient care activities and patient outcomes, while controlling for confounding factors related to workload, and nurse, patient, team, and organizational characteristics.

Modeling informatics data to track maternal risk and care quality

Principal Investigators: Sarah Rossetti, Alexander Friedman

Funding: Eunice Kennedy Shriver National Institute of Child Health and Human Development

The overarching hypothesis of this study is that EHR data can reliably identify clinical-management factors associated with failure to rescue in the setting of maternal emergencies such as: (i) severe hypertension, (ii) obstetric hemorrhage, (iii) sepsis, and (iv) frankly abnormal maternal vital signs (maternal early warnings systems). The study will also analyze to what degree care follows bundle recommendations and estimate risk for failure to rescue when guidelines are not followed.

Development and Testing of MyPEEPS Mobile for Young Transgender Men

Principal Investigators: Rebecca Schnall, Robert Garofalo

Funding: National Institute of Mental Health

This study is developing MyPEEPS Mobile for young transgender males (YTM,) and conducting a pilot randomized controlled trial to examine the feasibility, acceptability, and preliminary efficacy of the revised MyPEEPS Mobile App in a sample of 80 YTM (15-19 years), assessing predisposing, enabling, and reinforcing factors for MyPEEPS Mobile among YTM through theoretically-guided in-depth interviews. 

mLab App for Improving Uptake of rapid HIV self-testing and Linking Youth to Care

Principal Investigators: Rebecca Schnall, Robert Garofalo

Funding: National Institute of Mental Health

This project will refine and test a next- generation diagnostic intervention delivered on a mobile platform to improve HIV testing and linkage-to-care outcomes among youth living with and at-risk for HIV and then enroll 500 high-risk youth (age 17-29 years) in a 12-month RCT to assess differences in HIV testing rates and linkage to care between the intervention (mLab App) and control arm.

CHAMPS: A randomized trial of a Community Health Worker intervention for persons living with HIV in two high priority settings

Principal Investigators: Rebecca Schnall, David Batey

Funding: National Institute of Nursing Research

The proposed study blends the strengths of the BA2C and WiseApp interventions to test a rigorous and reproducible CHW intervention to improve viral suppression and ART adherence. The proposed study will test the clinical efficacy of the Community Health Workers And MHealth to ImProve Viral Suppression (CHAMPS) intervention and assess implementation factors to inform future implementation and scale-up of CHAMPS. 

Development and Pilot Testing of a Just in Time Mobile Smoking Cessation Intervention for Persons living with HIV

Principal Investigators: Rebecca Schnall, Ming-Chun Huang

Funding: National Cancer Institute

This study if focused on systematically developing and pilot testing the Sense2Quit App to improve tobacco cessation in persons living with HIV (PLWH). 

Dissemination of the WiseApp for Improving Health Outcomes Across Settings

Principal Investigator: Rebecca Schnall

Funding: Agency for Healthcare Research and Quality

This study explores the transferability of the WiseApp to Latinos in the US and the Dominican Republic (DR) by translating and culturally adapting it and conducting a multi-site RCT to assess its efficacy. 

mChoice: Improving PrEP Uptake and Adherence among Minority MSM through Tailored Provider Training and Adherence Assistance in Two High Priority Settings

Principal Investigator: Rebecca Schnall

Funding: National Center for HIV/AIDS

This study includes a Hybrid Type II trial simultaneously testing the effectiveness of a culturally congruent clinical intervention (mChoice App) and an implementation intervention (practice facilitation) guided by complementary implementation and evaluation frameworks–the Consolidated Framework for Implementation Research (CFIR) and Reach, Effectiveness, Adoption, Implementation, and Maintenance (RE-AIM). 

Examining Social Ecological and Network Factors to Assess Epidemiological Risk in a Large National Cohort of Cisgender Women

Principal Investigator: Rebecca Schnall, Amy Kristin Johnson, Mirjam-Collete Kempf

Funding: National Institute for Allergy and Infectious Diseases

This study harnesses innovative digital methods to establish a knowledgebase for women living in the US who are behaviorally vulnerable to HIV. The knowledgebase will consist of a national cohort of 1,800 women from whom we will collect HIV and sexually transmitted infections (STIs) incidence data and social and sexual network data, paired with open-source big data to contextualize HIV risk among women vulnerable to HIV infection. The knowledgebase will be used to identify theoretically-driven correlates of HIV seroconversion, STI incidence, and predictors of PrEP uptake. 

MyPEEPS Mobile LITE: Limited Interaction Efficacy Trial of MyPEEPS Mobile to Reduce HIV Incidence and Better Understand the Epidemiology of HIV among YMSM

Principal Investigator: Rebecca Schnall, Dustin Duncan, Robert Garafolo

Funding: National Institute for Allergy and Infectious Diseases

This study is a virtual, digital clinical trial testing whether MyPEEPS Mobile (an evidence-based mHealth HIV prevention intervention) reduces HIV incidence among HIV-negative YMSM (17-25 years old) looking at the influence of theory-driven social, ecological, and geospatial factors on intervention uptake and efficacy inclusive of measures that align with traditional models of behavior change such as the Information Motivation Behavior

Homecare-CONCERN: Building risk models for preventable hospitalizations and emergency department visits in homecare

Principal Investigator: Max Topaz

Funding: Agency for Healthcare Research and Quality

The aims of this study are to further develop and validate a preventable hospitalization or Emergency Department visit risk prediction model (Homecare- CONCERN) and to prepare Homecare-CONCERN for a future clinical trial. 

Improving patient prioritization during hospital-homecare transition: A mixed methods study of a clinical decision support tool

Principal Investigator: Max Topaz

Funding: National Institute of Nursing Research

The aims of this study are to evaluate the effectiveness of the “Priority for the First Nursing Visit Tool” (PREVENT) tool on process and patient outcomes and to explore PREVENT’s reach and adoption by the homecare admission staff.

Data-driven shared decision-making to reduce symptom burden in atrial fibrillation

Principal Investigator: Meghan Turchioe

Funding: National Institute of Nursing Research

The specific aims of this project are to (1) identify common symptom patterns in patients with paroxysmal atrial fibrillation (AF) post-catheter ablation (n>32,014); (2) develop and evaluate decision-aid visualizations of common AF symptom patterns (n=50); and (3) evaluate the feasibility of implementing the decision-aid visualizations in clinical practice (n=75).

Cortical subcortical reorganization and risk behaviors of early alcohol use initiation

Principal Investigator: Yihong Zhao, Marc Potenza

Funding: National Institute of Alcohol Abuse and Alcoholism

This study uses data from the longitudinal Adolescent Brain Cognitive Development (ABCD) study to investigate the neural substrates that are predictive of early initiation of alcohol use and its risk precursors. 

Use of advanced analytics to understand brain-behavior screen media activity relationships in ABCD data

Principal Investigator: Yihong Zhao, Marc Potenza

Funding: National Institute of Mental Health

This study uses data from the longitudinal Adolescent Brain Cognitive Development (ABCD) study to investigate network-level neural substrates linked to SMA, sleep disturbances and other clinically relevant measures. Multiple advanced analytical approaches will be used to extract novel features at both structural and functional levels. 

MCI-ED Screen: A speech-processing algorithm for automatic screening of patients with mild cognitive impairment (MCI) and early dementia (ED) in the home healthcare setting

Principal Investigator: Maryam Zolnoori

Funding: National Institute of Aging

The primary goal of the project is to utilize the routinely generated data in the HHC setting, including OASIS (Outcome and Assessment Information Set - a federally required assessment of patients admitted to HHC), HHC nurses’ notes, and HHC patient-nurse verbal communication to develop a mild cognitive impairment-early stage dementia screening algorithm.