Research Studies

Multiple Principal Investigators: Maxim Topaz PhD, RN, MA, Scott Sittig, PhD, MHI, RHIA, Jacquelyn Taylor PhD, PNP-BC, RN, FAHA, FAAN

Funded by: NIH/NIMHD

This study includes two of the largest providers of home healthcare (HHC) services in the US (Louisiana Health Care [LHC] Group and VNS Health), with more than 100,000 patients on the combined daily census. The MPIs assembled a team of experts in linguistics, health disparities, HHC nursing, qualitative analysis, and natural language processing (NLP) to design a nurse-centered NLP-based system to rEduce stigmatiziNG languAGE ("ENGAGE").

Principal Investigator: Veronica Barcelona, PhD, MSN, RN, PHNA-BC

Funded by: NIH/NICHD)

This study examines racial and ethnic group differences in preterm birth (PTB); and then examines multilevel (the interaction of individual and structural) racism in the whole group to determine if racism explains the excess PTB observed in non-Hispanic Black and Hispanic women.

Principal Investigator: Veronica Barcelona, PhD, MSN, RN, PHNA-BC

Self-Selected Mentor: Suzanne Bakken, Ph.D., R.N., F.A.A.N., F.A.C.M.I., F.I.A.H.S.I.

Program-Appointed Mentor: Rose L. Horton, R.N.C.-O.B., N.E.A-B.C., F.A.A.N.

Funded by: Betty Irene Moore Fellowship for Nurse Leaders and Innovators

This study uses natural language processing (NLP) to identify stigmatizing language in the electronic health records of birthing people.

Multiple Principle Investigators: Karen L. Saban, PhD, RN, CNRN, FAHA, FAAN, and Jacquelyn Y. Taylor, PhD, PNP-BC, FAHA, FAAN

Funded by: NIH/NHLBI

The Impact of a Race-Based Stress Reduction Intervention on Well-Being, Inflammation, and DNA Methylation in African American Women at Risk for Cardiometabolic Disease (RiSE Study)

The RiSE study aims to improve psychological well-being and reduce inflammatory burden, with potential to ameliorate the progression of cardiometabolic disease (CMD). In addition, DNAm will be evaluated as the molecular basis for the observed psychological and inflammatory outcomes. The rationale for the proposed study is supported by allostatic load theory, which posits that cumulative life stress, including chronic racism and discrimination, predisposes individuals to inflammatory burden and risk for chronic disease. African American women (50 to 75 years of age) with CMD risk will be recruited from Chicago and New York City. Participants will be randomized to either the RiSE or Health Education Program (HEP) (attention control) program. 

Primary Investigator: Marisa N. Spann PhD and Jacquelyn Taylor, PhD, PNP-BC, RN, FAHA, FAAN

Funded by: NCATS

The overarching goal of the Irving Institute's NRSA Training Core is to bring together pre-doctoral and post-doctoral trainees from across the broad spectrum of medicine, the other health sciences, and the basic sciences at Columbia University (CU), and prepare them to be leaders of the next generation of clinical and translational investigators. The Training Core, designated as a TL1 by NCATS, is founded upon a typical NRSA T32 training program, but has unique and innovative features distinguishing it from other T32 programs including the 47 at CU. For example, the TL1 is deeply integrated into our overall Clinical and Translational Science Award (CTSA) Program hub training and education program, TRANSFORM (Training and Nurturing Scholars For Research that is Multidisciplinary), which enables trainees to participate in didactic and experiential programs, including programs focused on team-science, alongside scholars in the KL2 and Master's Degree in Patient Oriented Research programs. The Irving Institute's TL1 also differs from a typical T32 in its disease agnostic approach to recruitment and enrollment of trainees, and the designed focus on Precision Medicine (PM). As such, the program is named TL1-PM. The focus on PM has been stimulated by the CU-wide initiative in PM. Based on experiences during the first funding cycle, as well as the evolution of PM programs at CU, the Specific Aims for the renewal are: Aim 1. To further develop and refine our innovative TL1-PM education and career development program, thereby empowering our scholars and trainees to use the principles of PM to engage in interdisciplinary team science across all translational domains, make new discoveries, and be equipped to implement those discoveries into clinical practice and patient benefit. This TL1 is innovative in its focus on PM, significant coursework and seminars, a structured career development curriculum, and requiring all trainees to take externships. In the next five years, new opportunities will be added, including some focused on team and implementation science. Less successful programs will be scaled back or ended. Aim 2. To demonstrate the effectiveness of existing and new programs through continuous monitoring and assessment for quality improvement, using NCATS Common Metrics as well as our local, customized metrics to evaluate the impact of our educational programs on research output and the career trajectories of our graduates. Aim 3. To accelerate dissemination of the results of novel educational delivery approaches, new methods for assessing trainee learning, and best practices for enhancing interdisciplinary team science skills, to our partners at CU, regional CTSA Hubs (TriCon), and CTSA Program network throughout the nation.

Primary Investigators: Gbenga Ogedegbe, M.D., M.P.

Co-Investigators: Stephen P. Juraschek, M.D., M.P.H, Yvonne Commodore-Mensah Phd, MHS, BSN, RN, FAAN, FAHA, FPCNA, Joseph Ravenell, M.D, Phillip Levy, M.D., M.P.H., Andrea Cherrington, M.D., M.P.H, Jacquelyn Taylor, PhD, PNP-BC, RN, FAHA, FAAN

Funded by: AHA

The name of this study is the overarching research program. It is managed by a multidisciplinary team, led by the coordinating center will oversee the establishment of and provide support and resources to the five research projects. The RESTORE Network will be testing multiple approaches to helping people overcome the barriers to health faced by many living in neighborhoods with poor access to health care, healthy foods, and places to exercise.

Primary Investigators: Sachin Agarwal, MD, MPH, Clifton W. Callaway, MD, PhD

Co-Investigators: Jacquelyn Taylor, PhD, PNP-BC, RN, FAHA, FAAN

Funded by: NINDS

This study will be among the first to focus on a new equitable science of out-of-hospital cardiac arrest (OHCA) survivorship itself, seeking empirically derived targets for preserving or restoring recovery. This study aims to describe patient variability in recovery (i.e., improvement in functional, cognitive, and health-related quality of life outcomes) from 3 to 12 months after OHCA, and test whether changes are associated with illness severity scores, and critical care interventions performed during the acute care stay. Additionally, this study will test whether receipt of acute inpatient rehabilitation (vs outpatient therapy/no therapy/skilled nursing facility) within 1 month of hospital discharge is associated with greater improvement in recovery outcomes from 3 to 12 months. Finally, this study will test whether non-Hispanic Black and Hispanic/Latinx patients have less favorable changes in recovery outcomes between 3 and 12 months and explore mechanisms for such disparities.

Primary Investigators: Billy Caceres, PhD, RN, AGPCNP-BC

Funded by: NHLBI

The overall goal of this 1-week daily diary study is to estimate the influence of intersectional anticipated and vicarious stigma on home blood pressure. This study triangulates robust methods to examine mechanisms linking daily and chronic anticipated and vicarious stigma with BP in individuals’ real-world environments. Participants will complete a structured interview followed by 1 week of twice-daily structured electronic diaries that will assess daily anticipated, vicarious, and enacted stigma, collection of saliva samples to assess salivary stress biomarkers, continuous wrist-worn actigraphy, and twice daily home BP monitoring. This information will determine the influence of intersectional anticipated and vicarious stigma on mean home systolic BP and mediators of these associations (e.g., salivary cortisol, physical activity, rumination) and examine differences in intersectional anticipated and vicarious stigma and mean home systolic BP across social identities (i.e., gender, ethnoracial, and sexual identity) and the intersections between them.

Primary Investigators: Olugbenga G. Ogedegbe, MD, MPH, Nadia S. Islam, PhD, Antoinette M. Schoenthaler, EdD

Co-Investigators: Jacquelyn Taylor, PhD, PNP-BC, RN, FAHA, FAAN

Funded by: NHLBI

This program provides mentorship, training, and advanced research experience with a focus on scalability, a desired outcome in implementation science. This program aims to assess the potential scalability of the Practice support And Community Engagement (PACE) intervention through active stakeholder engagement, to identify barriers and facilitators to the scalability of this MEBI. This program aims to evaluate the context, barriers, and facilitators to blood pressure control intervention at primary care practices in New York City, assess the potential for scalability of the PACE intervention, develop a robust operational process and logic model that will guide horizontal and vertical scale-up of PACE, and assess the feasibility of the model via stakeholder feedback, and engage in coursework, training, and mentorship to increase knowledge in implementation research by participating in coursework and training.

Principal Investigator: Jacquelyn Y. Taylor, PhD, PNP-BC, FAHA, FAAN

Co-Principal Investigator: Cleopatra Caldwell, PhD

The ultimate goal of this study (known as FlintGEMS) is to examine the main interaction effects of genetics, psychosocial factors, and blood levels of lead in parent-child groups in Flint, Michigan, as well as to assess the role of risk factors and protective psychosocial factors in this process on the symptom of interest (high blood pressure in African American families) and the population’s outcomes. This pilot study is led by the Columbia University School of Nursing and the University of Michigan.

Primary Investigators: Uma Reddy, MD, Kelli Hall, PhD, Jacquelyn Y. Taylor, PhD, Lauren Stidham Osborne, MD, Monika M. Safford, MD, Sevonna Brown, Madeleine Dorval-Moller, Emilie M Rodriguez, Victoria St. Clair

Funded by: NIH/NICHD

NY Community-Hospital-Academic Maternal Health Equity Partnerships (NY-CHAMP)

The broad goal of the NY- CHAMP is to upend the maternal healthcare ecosystem in New York City (NYC) and New York State (NYS) by establishing a sustainable, highly collaborative infrastructure for community-centered maternal health science. 

Principle Investigators: Henry N Ginsberg, MD, Muredach P Reilly, MD, and Jacquelyn Taylor, PhD, PNP-BC, RN, FAHA, FAAN

Funded by: NIH/NHLBI

Postdoctoral Training in Arteriosclerosis Research

This program consists of eight training positions, for the post-doctoral T32 program, “Training in Arteriosclerosis Research” that began in 1978. The goal of this program is to provide basic and clinical investigators with broadly based knowledge in scientific fields related to atherosclerotic cardiovascular disease, which has a major impact on the health of the American population. This training program is, therefore, very relevant to the mission of NHLBI. This T32 functions within a broad framework of research addressing various aspects of cardiovascular disease and the spectrum of biologic and social determinants, including diabetes, obesity, dyslipidemia, hypertension, sleep disorders, and health disparities that increase the risk for atherosclerosis. A major strength of the program is the many collaborations that exist between faculty mentors. The training program has a long record of success, with over 75% of trainees that completed the program presently in research positions, mostly in academic centers and funded by NIH and foundations.

Primary Investigator: Jacquelyn Y. Taylor, PhD, PNP-BC, FAHA, FAAN

Funded by: NIH/NHLBI

The program aims to identify, train, and provide longitudinal support to expand the next generation of diverse, interdisciplinary physician-scientists to advance outcomes and reduce disparities for patients with heart, lung, blood, and sleep-related diseases.

Primary Investigators: Olajide Williams, MD, MS and Randolph Marshall MD, MS

Co-Investigator: Jacquelyn Y. Taylor, PhD, PNP-BC, FAHA, FAAN

Funded by: NIH/NINDS

This study uses a pragmatic community-based randomized clinical trial (RCT) to evaluate the effect of a Social Determinants of Health (SDOH)-Homecare Intervention Focus Team (SHIFT) on stroke-related outcomes.

Primary Investigators: Victoria Vaughan Dickson, FAAN FAHA FHFSA PhD RN and Jacquelyn Taylor, PhD, PNP-BC, RN, FAHA, FAAN

Funded by: NIH/NLHB

Research Education in Cardiovascular Conditions Program

Project Summary/Abstract The goal of this innovative program “Research Education in Cardiovascular (CV) Conditions (RECV)” is to develop, implement, and evaluate a short-term program that offers a broad knowledge base on CV risk factors, health disparities, and innovative research methods and analyses (e.g., advanced statistical methods, genomics); and provide cutting edge research and scholarship experiences in team science and individualized mentoring. We will recruit and enroll underrepresented minority undergraduate and graduate students who are interested in research education in the prevention and management of CVD. The proposed RECV is a 10- week summer research intensive program that leverages the resources and expertise of NYU Meyers as well as those across NYU (including the School of Medicine (e.g., AHA Soter Center for Women's Cardiovascular Research); Department of Population Health (e.g., NYU PRIDE); College of Dentistry; College of Global Public Health; and the Silver School of Social Work) to provide interdisciplinary and team science training and research opportunities, thereby contributing to an increased number of promising diverse interdisciplinary scientists committed to future biomedical, behavioral and clinical CV research. Specific aim 1 is to develop, implement and sustain a 10-week interdisciplinary RECV program that provides individual mentorship and group-based education along with applied learning experiences. Together with interdisciplinary NYU faculty experts in CVD, we will develop and implement the RECV curriculum and applied/hands-on research experiences. Further, we will establish an Advisory Committee to provide oversight and recommendations for the program, particularly on evaluation and sustainability. Specific aim 2 is to recruit, enroll, and retain an interdisciplinary cohort of 10 underrepresented minority undergraduate (n=6) and graduate (n=4) students annually into the RECV program. We will recruit students from underrepresented populations from NYU, New York City, and outside the region using multi-faceted strategies. Specific aim 3 is to evaluate the success of the RECV program. To accomplish this aim we will evaluate student and faculty mentor satisfaction and program goal attainment, establish a RECV Research Meeting for presentations of student-faculty research products, track student progress in the program, evaluate students' future plans for educational and career development upon RECV completion and yearly for the duration of the award, and establish a network of RECV program alumni and research mentors to support trainee career trajectories that prepare them to pursue future competitive fellowships and other CVD research training. The expected outcome is a sustainable RECV program that supports interdisciplinary training of a diverse cohort of future scientists who will become pioneers in CV health-related research engaged in team science. Our RECV supports the NHLBI strategic plan to enhance the diversity of the biomedical, behavioral, and clinical research workforce.

Principle Investigator: Jacquelyn Y. Taylor, PhD, PNP-BC, FAHA, FAAN

Funded by: NIH/NINR

The Presidential Early Career Award for Scientists and Engineers (PECASE) that is funding this study was presented to Jacquelyn Y. Taylor by President Barack Obama in 2017. It is the highest honor awarded by the federal government to scientists and engineers. The project is looking at interactions between next-generation sequencing and the environment on blood pressure among African Americans. The project is examining the lack of knowledge about potentially and likely pathogenic variants among African American populations and the lack of inclusion within medicine for the needs of those populations. In addition, it aims to provide recommendations for whole genome sequencing as a screening tool in community and clinical settings for use in early detection and treatment of cardiovascular-related diseases, in an effort to help reduce this health disparity.

Principal Investigator: Jacquelyn Y. Taylor, PhD, PNP-BC, FAHA, FAAN

Co-Principal Investigator: Cindy A. Crusto, PhD

High blood pressure (hypertension) in children is a growing public health concern, given significant recent increases in blood pressure levels among children in the United States. Racial/ethnic disparities have been linked to the prevalence of hypertension in children; Black/African American children in particular are at increased risk for hypertension. Black/African American populations develop high blood pressure more often and at an earlier age than Whites and Hispanics, and more Black women than men have high blood pressure. This study (known as InterGEN) sought to reduce hypertension health disparities among underserved Black/African American children and their mothers by conducting community-based research to better understand the genetic, psychological, and environmental factors that may contribute to high blood pressure.

Principal Investigator: Jacquelyn Y. Taylor, PhD, PNP-BC, FAHA, FAAN

Intramural Principal Investigator: Paule V. Joseph, PhD, MS, FNP-BC, RN, CTN-B

Funded by: NIH/NINR

This was a contract to run whole genome sequencing (WGS) on DNA samples obtained from Jacquelyn Y. Taylor’s InterGEN study, described above. The purpose of this project was to identify across generations in this racial/ethnic group the most frequent disease-associated variants for high blood pressure and other common and chronic cardiovascular-related diseases. Each participant in the study had their sequence analyzed by a SNP array harboring about two million features, allowing a standard genome-wide association study (GWAS) data set to be built; in addition, each individual had WGS, generating a state-of-the-art, foundational resource for the African American community. We utilized our African American cohorts and compared the results with diverse cohorts to search for strong effects specific to African American populations.

Primary Investigator: Jacquelyn Y. Taylor, PhD, PNP-BC, FAHA, FAAN

Co-Investigator: Yan V. Sun, PhD

Funded by: NIH/NIMHD

This study examined the protein-coding regions of the genome and how these regions, along with environmental interactions, can influence outcomes for cardiovascular disorders. The study specifically examined mother and child participants within the InterGEN study described above.

Principal Investigator: Veronica Barcelona, PhD, MSN, MPH, RN, PHNA-BC

Primary Mentor: Jacquelyn Y. Taylor, PhD, PNP-BC, FAHA, FAAN

Funded by: NIH/NINR

This study is investigating how health during pregnancy and children’s genetics and epigenetics may influence blood pressure among African American children—especially how preterm birth or preeclampsia may influence their health. This is a substudy that enrolled 100 children from the Intergenerational Impact of Genetic and Psychological Factors on Blood Pressure (InterGEN) study.